Communications in Information and Systems

Volume 18 (2018)

Number 3

Wavelet analysis of candidate genes for diabetic retinopathy

Pages: 149 – 171

DOI: http://dx.doi.org/10.4310/CIS.2018.v18.n3.a2

Author

En-Bing Lin (Department of Mathematics, Central Michigan University, Mt. Pleasant, Mich., U.S.A.)

Abstract

Diabetic retinopathy, a major cause of adult blindness, is a medical condition in which damage occurs to the retina due to diabetes mellitus. Based on the Diaretinopathy database, we perform wavelet analysis on several candidate genes responsible for causing diabetic retinopathy. We obtain approximation and detail information of the numerical representations of candidate genes. We compute discrete and continuous wavelet transforms of each gene. We compare the computational and graphical results of seven candidate genes. We also perform wavelet analysis and wavelet transform on the Fibroblast Growth Factor 21 gene which can be included in the gene therapy. Through this study, it is anticipated to provide better disease management and ensure better prognosis in diabetic retinopathy.

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Dedicated to the memory of my parents: Dr. and Mrs. Chen-Chuan Lin