Communications in Mathematical Sciences
Volume 14 (2016)
A hierarchical extension scheme for solutions of the Wright–Fisher model
Pages: 1093 – 1110
We develop a global and hierarchical scheme for the forward Kolmogorov (Fokker–Planck) equation of the diffusion approximation of the Wright–Fisher model of population genetics. That model describes the random genetic drift of several alleles at the same locus in a population. The key of our scheme is to connect the solutions before and after the loss of an allele. Whereas in an approach via stochastic processes or partial differential equations, such a loss of an allele leads to a boundary singularity, from a biological or geometric perspective, this is a natural process that can be analyzed in detail. Our method depends on evolution equations for the moments of the process and a careful analysis of the boundary flux.
Wright–Fisher model, forward Kolmogorov equation, random genetic drift, hierarchical solution
2010 Mathematics Subject Classification