Statistics and Its Interface
Volume 9 (2016)
An invariant allocation function for multi-treatment clinical trials
Pages: 1 – 10
An allocation function, invariant under monotonic transformation, is proposed in the context of multi-arm clinical trials for a class of continuous response distributions. The aim is to skew the allocation towards the most promising treatment using the whole information about the response distributions. A response adaptive implementation based on the proposed allocation function is suggested and assessed through some useful performance measures.
response adaptive allocation, clinical trial, censoring
2010 Mathematics Subject Classification
Primary 62L05. Secondary 62G05.