Communications in Information and Systems

Volume 15 (2015)

Number 1

Switched systems as models for dynamic clinical trials

Pages: 35 – 46



Y. Du (Division of Biostatistics, University of Texas School of Public Health, Houston, Tx., U.S.A.)

C. Martin (Department of Mathematics and Statistics, Texas Tech University, Lubbock, Tx., U.S.A.)


The goal of the paper is to make a case for the use of switched systems as a model for the simulation of dynamic clinical trials. Dynamic clinical trials are characterized by the use of different treatments based on the response of a patient to the current treatment. We show that switched systems are, in fact, a suitable model for these trials.


dynamic clinical trials, switching systems, stability

Published 18 November 2015