Communications in Information and Systems

Volume 19 (2019)

Number 4

Comparisons of BRAT1 gene variants

Pages: 375 – 390



En-Bing Lin (Department of Mathematics, Central Michigan University, Mt. Pleasant, Mich., U.S.A.)

Eric Linton (Department of Biology, Central Michigan University, Mt. Pleasant, Mich., U.S.A.)


BRAT1 (BRACA1 Associated ATM Activator 1) is a protein coding gene that interacts with and activates the tumor suppressor gene BRCA1, a protein complex that repairs DNA damage due to ionizing radiation. In this paper, we obtain approximation and detail information of the numerical representation, i.e. wavelet transformation with Daubechies 2 and Coiflet, of the gene variants. We compare the computational and graphical results of these gene variants to each other, as well as to those obtained from BLAST (Basic Local Alignment Search Tool). Thus, we can compare the results of an alignment free search method (wavelet) to that of an alignment dependent search method (BLAST). In general, both methods located the same areas of similarity but the results of the wavelet analysis provide numerical and visual comparisons. We also conclude with some other advantages of using wavelet method.

Received 30 September 2019

Published 15 April 2020